Renal anaphylaxis. I. Antigen-initiated responses from isolated perfused rat kidney
نویسندگان
چکیده
منابع مشابه
The Isolated Perfused Rat Kidney
1. In the isolated rat kidney, perfused at constant pressure with a medium free from renin substrate, addition of angiotensin I to the perfusate decreases renal 'plasma' flow. 2. A peptide inhibitor, SQ 20881, of converting enzyme reduces the vasoconstrictor effect of angiotensin I up to a maximum of 87%, the degree of inhibition being dose-dependent. 3. The molar ratio of equi-effective doses ...
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Nephrotoxicity is an important limitation to the clinical use of colistin against Pseudomonas aeruginosa and other gram-negative pathogens. Previous work reported net tubular reabsorption of colistin by the kidney in vivo, but there is no knowledge of its disposition within the kidney. This study investigated the renal disposition and potential transport mechanisms of colistin in the isolated p...
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The perfused rat kidney was used for a study of gluconeogenesis. The kidney was completely isolated and perfused with Krebs-Henseleit bicarbonate buffer containing 5% albumin. Perfusion flow rate and pressure remained stable for 2 to 3 hours, although the glomerular filtration rate diminished with time. The fractional reabsorption of both water and sodium was 0.92 during the 1st hour of perfusi...
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1 The vascular effects of leukotriene C4 (LTC4) were investigated in the isolated perfused kidney of the rat. 2 LTC4 (6.4 X 10(-10) to 3.2 X 10(-8) mol kg-1 min-1 given over 5 min) resulted in a prompt, dose-dependent increase in renal vascular resistance in a recirculating system, which lasted for more than 60 min. 3 LTC4 was 10 to 20 fold and 1000 to 2000 fold, respectively, less active on a ...
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Controversial results regarding the role of vasopressin as a mediator of ethanol-induced diuresis raise the question, whether ethanol may stimulate diuresis directly on the level of the kidney, possibly by its vasodilating properties. We thus studied the effects of different ethanol-concentrations (0.5 ‰, 1 ‰, 2 ‰, and 4 ‰; n = 4 to 6, respectively) – in the presence of 10 mU/l vasopressin in t...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1987
ISSN: 0085-2538
DOI: 10.1038/ki.1987.197